Figure 1.

Flow chart of the study design. A retrospective review of medical records was undertaken for 392 patients with primary biliary cholangitis (PBC). In total, 227 patients with PBC who were not histologically confirmed or in whom not all 10 serum fibrosis indices, such as platelet (PLT) count, serum levels of HA, type IV collagen 7 second domain (7S collagen), procollagen type III amino-terminal peptide (PIIINP), metalloproteinase 1 (TIMP-1), Mac-2 binding protein glycosylation isomer (M2BPGi), N-terminal type III collagen propeptide (Pro-C3), fibrosis index based on 4 factors (FIB-4 index), aspartate aminotransferase-to-platelet ratio index (APRI), and enhanced liver fibrosis (ELF) scores, were not determined were excluded. The inclusion criteria were met by 102 out of 392 patients.