Table 2.

Diagnostic accuracy of serum fibrosis markers for patients with PBC in Scheuer stage III.

Variable	Cut-off	Sensitivity (95% CI)	Specificity (95% CI)	AUC (95% CI)	PPV (95% CI)	NPV (95% CI)	Accuracy (95% CI)	P
ELF score	10.0	92.3 (0.669–0.987)	66.7 (0.583–0.810)	0.81 (0.67–0.92)	45.9 (0.295–0.631)	96 (0.863–0.995)	74.7 (0.643–0.834)
TIMP-1	270	76.9 (0.462–0.950)	72.2 (0.604–0.821)	0.75 (0.59–0.92)	33.3 (0.173–0.528)	94.5 (0.849–0.989)	72.9 (0.622–0.820)	.538
P-III-P	13.5	76.9 (0.462–0.950)	74.6 (0.629–0.842)	0.80 (0.69–0.94)	35.7 (0.186–0.559)	94.6 (0.851–0.989)	75.0 (0.644–0.838)	.94
HA	125	53.3 (0.266–0.787)	76.6 (0.656–0.855)	0.67 (0.50–0.83)	30.8 (0.143–0.518)	89.4 (0.794–0.956)	72.8 (0.626–0.816)	.059
Pro-C3	12.5	94.4 (0.727–0.999)	38.1 (0.277–0.493)	0.74 (0.62–0.86)	24.6 (0.151–0.365)	97.0 (0.842 – 0.999)	48.0 (0.380–0.582)	.821
M2BPGi	0.9	66.7 (0.349–0.901)	61.4 (0.490–0.728)	0.63 (0.45–0.81)	22.9 (0.104–0.401)	91.5 (0.796–0.976)	62.2 (0.508–0.727)	.046
Fib-4 index	2.16	69.2 (0.386–0.909)	57.9 (0.460–691)	0.64 (0.48–0.80)	22.0 (0.106–0.376)	91.7 (0.800–0.977)	59.6 (0.486–0.698)	.156
APRI	0.73	84.6 (0.546–0.981)	59.2 (0.473–0.704)	0.74 (0.62–0.85)	26.2 (0.139–0.420)	95.7 (0.855–0.995)	62.9 (0.525–0.729)	.859
7S collagen	4.1	73.3 (0.449–0.922)	59.2 (0.473–0.704)	0.65 (0.49–0.81)	26.2 (0.139–0.420)	91.8 (0.804–0.977)	61.5 (0.508–0.716)	.647
Platelet	22.9	71.4 (0.419–0.916)	51.9 (0.403–0.635)	0.67 (0.53–0.82)	21.3 (0.107–0.357)	90.9 (0.783–0.975)	54.9 (0.442–0.654)	.129

4C7S = 7S domain of type 4 collagen, APRI = the aspartate aminotransferase-to-platelet ratio index, ELF score = Enhances Liver Fibrosis score, Fib-4 = the fibrosis index based on four factors, M2BPGi = Mac-2-binding protein glycosylation isomer, PBC = primarily biliary cholangitis, Pro-C3 = N-terminal type III collagen propeptide.