Table 4.

Univariate and multivariate analysis of patients with anastomosis

	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Male sex	1.73 (0.71–4.23)	0.23
Duration of disease	0.99 (0.98–1.00)	0.11
Age at the index surgery	1.01 (0.97–1.05)	0.60
Surgery history	0.05 (0.00–256.57)	0.49
Age at diagnosis	1.02 (0.99–1.06)	0.21
Site of resection	—	0.38
Penetrating vs stricturing phenotype	1.89 (0.86–4.16)	0.11	1.22 (0.47–3.20)	0.68
Perianal disease	0.91 (0.43–1.96)	0.82
Smoking history (yes vs no)	2.67 (1.18–6.01)	0.02 *	2.88 (1.07–7.70)	0.04*
Postoperative biologics vs immunosuppressants	0.04 (0.00–116.84)	0.44
Postoperative biologics vs none	0.04 (0.00–57.02)	0.38
Postoperative immunosuppressants vs none	0.83 (0.39–1.77)	0.63
LME vs EME	2.78 (1.07–7.24)	0.04*	2.83 (1.01–7.96)	0.048*

CI, confidence interval; EME, extensive mesenteric excision; HR, hazard ratio; LME, limited mesenteric excision.

^*P< 0.05.