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. 2021 Apr 29;12(5):1911–1929. doi: 10.1093/advances/nmab033

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© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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The ratio of reaction rates for alternative substrates when, in a common reaction, volume is proportional to the ratio of the substrate concentrations and their kcat/Km values. The ratio of kcat/Km of PL () to kcat/Km of PN () predicts that PNP formation will be favored over PLP formation at PL-to-PN ratios <7.5. For a similar level of inhibition as the PDXK deficiency (37.5% capacity of WT Vmax), a PL:PN of 5.5 is necessary (47, 128, 133). dPLPdt/dPNPdt, the time derivative of PLP concentration over the time derivative of PNP concentration; kcat, catalytic constant; Km, Michaelis Menten constant; PDXK, pyridoxal kinase; PL, pyridoxal; PLP, pyridoxal 5′-phosphate; PN, pyridoxine; PNP, pyridoxine-5'-phosphate; Vmax, maximal rate; WT, wild type.

Inline graphic — The ratio of reaction rates for alternative substrates when, in a common reaction, volume is proportional to the ratio of the substrate concentrations and their kcat/Km values. The ratio of kcat/Km of PL () to kcat/Km of PN () predicts that PNP formation will be favored over PLP formation at PL-to-PN ratios <7.5. For a similar level of inhibition as the PDXK deficiency (37.5% capacity of WT Vmax), a PL:PN of 5.5 is necessary (47, 128, 133). dPLPdt/dPNPdt, the time derivative of PLP concentration over the time derivative of PNP concentration; kcat, catalytic constant; Km, Michaelis Menten constant; PDXK, pyridoxal kinase; PL, pyridoxal; PLP, pyridoxal 5′-phosphate; PN, pyridoxine; PNP, pyridoxine-5'-phosphate; Vmax, maximal rate; WT, wild type.