Effect of exosome and LNP injections on organ histology and body mass. A, hematoxylin and eosin staining of tissue sections from BALB/c mice that had been injected 3 days earlier with 0.050 ml of PBS, exosomes (1.5 × 1010), or LNPs (1.5 × 1010). Note the hypertrophy of spleen red pulp in 4/5 animals injected with LNPs. Bar, 0.2 mm. B, bar graph displaying body mass measurements prior to and at 3 days after injection.