Figure 7.

Repeat dosing of mRNA-loaded exosomes leads to sustained mRNA expression. Combined light and bioluminescence images of mice that had been injected with 0.05 ml of mRNA loaded exosomes: (2 weeks) on days 0, 7, and 14, and imaged 1 day after the day 14 injection; (4 weeks) on days 0, 7, 14, 21, and 28, and imaged 1 day after the day 28 injection; (8 weeks) on days 0, 7, 14, 21, 28, 42, and 56 and imaged 2 days after the day 56 injection; and (10 weeks) on days 0, 7, 14, 21, 28, 42, and 56 and imaged 16 days after the day 56 injection. Bar, 1 cm. Light emission measured in radiance (photons/s/area (cm²)/steradian) is reflected in the color, with red denoting the areas of highest light emission and blue denoting the areas of lowest light emission. Five treated animals in total were used in these experiments.