Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 3;40(39):5829–5842. doi: 10.1038/s41388-021-01877-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — A–E Knockdown of RNF141 suppressed tumor growth in vivo. Images of LV-sh-NC or LV-sh-RNF141-transfected cell xenograft tumor models (A); Tumor growth curve (B) and average weight (C) were recorded and counted. The RNF141 protein level in xenograft tumors from LV-sh-NC or LV-sh-RNF141 group was confirmed by Western blot (D). The IHC staining (E) was applied to determine the expression of RNF141 and PCNA in LV-sh-NC or LV-sh-RNF141-transfected cell xenograft tumor. Scale bar, 50 μm. F–J RNF141 overexpression facilitated tumor growth in vivo. Xenograft tumor models of HCT116 cells transfected with LV-NC or LV-RNF141 were displayed (F), Tumor growth curve (G) and average weight (H) were recorded and counted. Western blot was performed to confirm RNF141 protein level in xenograft tumors from LV-NC or LV-RNF141 group (I). The IHC staining (J) was applied to determine the expression of RNF141 and PCNA in LV-NC or LV-RNF141-transfected cell xenograft tumor. Scale bar: 50 μm. Data represented mean ± SD. n = 6 each group. **P < 0.01, ***P < 0.001.