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. 2021 Aug 3;40(39):5829–5842. doi: 10.1038/s41388-021-01877-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A The effects of RNF141 knockdown on protein levels of MEK, p-MEK, ERK, p-ERK was assessed by Western blot. B, C Protein levels of PCNA, Cleaved caspase-3, Cleaved PARP, KRAS, and RNF141 in HCT116 (B) and HT29 (C) cells co-transfected with indicated siRNA and lentivirus were validated by Western blot. D, E Cell proliferation of HCT116, SW480, DLD-1 cells co-transfected with indicated siRNA and lentivirus was examined by CCK-8 assay (D) and plate colony formation assay (E). Data were mean ± SD from three independent experiments, each performed in triplicate. **P < 0.01, ***P < 0.001.