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. 2021 Aug 12;5(10):1415–1423. doi: 10.1038/s41559-021-01524-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Genotypes at 377 SNVs (columns) at the ASIP locus in grey wolves and dogs (rows), coded for heterozygosity (light blue), homozygosity for the reference (yellow) or the alternate (dark blue) allele or as missing genotypes (white). Alternate first exons (arrows) and nearby DY-associated structural variants (SINE insertions, green; polynucleotide expansions, orange) are included for reference. b, Maximum likelihood phylogenies, including seven extant canid species and the dog, from 48- and 16-kb intervals upstream or downstream of the HCP, respectively. Grey wolf/dog phyletic clades are highlighted with boxes to indicate relationships that are consistent (blue) or inconsistent (red) with genome-wide phylogenies. c, Images of a grey wolf, Arctic grey wolf and Tibetan wolf. d, A phylogeny representing distinct HCP evolutionary histories inferred from genetic variation in extant canids. Structural variants (as represented in Fig. 2) and derived SNVs (cyan) distinguish wolf-like canid (blue), ghost lineage (red) and basal canid (black) haplotypes.