Table 3.

Modification strategies of transport systems for GFAAs production.

Strains	Substrate	Titer (g/L)	Product	Cultivation	Modulations	Reference
C. crenatum CCM02	Glucose	19.56	Arginine	Shake flask; batch	the deletion of ncgl1221 gene	[19]
C. crenatum CCM05	Glucose	13.29	Arginine	Shake flask; batch		[54]
C. glutamicum Sorn2	Glucose	9.8	Ornithine	Shake flask; batch		[209]
C. glutamicum SA9	Glucose	0.616	5-ALA	Shake flask; batch		[207]
C. glutamicum SO17	Glucose	32.7	Ornithine	Shake flask; batch	the deletion of mscCG2 gene	[204]
C. crenatum SYPA-lysE	Glucose	35.9	Arginine	Bioreactor; fed-batch	the overexpression of lysE gene	[194]
C. glutamicum Sorn11	Glucose	18.4	Ornithine	Shake flask; batch		[209]
C. crenatum CCM06	Glucose	14.9	Arginine	Shake flask; batch	the insertion of a strong Psod promoter in the upstream region of lysE gene;	[54]
C. glutamicum orn8	Glucose	19	Ornithine	Shake flask; batch	the insertion of a strong mutant Ptac promoter in the upstream region of lysE gene	[205]
C. glutamicum SA13	Glucose	0.734	5-ALA	Shake flask; batch	the deletion of lysE and putP genes	[207]
C. glutamicum GABA6C	Glucose	9.8	GABA	Shake flask; batch	the deletion of yggB and cgmA genes	[72]
C. crenatum CCM02	Glucose	14.2	Arginine	Shake flask; batch	the deletion of putP gene	[54]
C. glutamicum Sorn4	Glucose	13.2	Ornithine	Shake flask; batch		[209]
C. glutamicum orn9	Glucose	20.6	Ornithine	Shake flask; batch	the insertion of a transcription terminator upstream of ncgl2228 gene	[205]
C. crenatum CCM04	Glucose	15.34	Arginine	Shake flask; batch	the deletion of cgl2310 gene	[54]
C. glutamicum ALA7	Glucose	3.14	5-ALA	Shake flask; batch	heterologous expression of rhtA gene from E. coli	[37]
C. glutamicum CgS1/pEC-SB-rhtA	Glucose	14.7	5-ALA	Shake flask; batch	the co-expression of hemA and RhtA genes	[199]
C. glutamicum SA15	Glucose	0.872	5-ALA	Shake flask; batch	heterologous expression of rhtA gene from E. coli	[207]