Table 4:

Associations of CVH score with GrimAA in FHS (N=2106)

Clinical CVH Score	Age Range	β (95% CI)†	P	Full CVH score	Age Range	β (95% CI)†	P
Prospective
Exam 7	33–85	−0.51 (−0.60, −0.42)	1.59E-27*	Exam 7	33–85	−0.83 (−0.92, −0.74)	8.35E-65*
Cross-sectional
Exam 8	40–92	−0.54 (−0.64, −0.44)	3.46E-25*	Exam 8	40–92	−0.76 (−0.86, −0.67)	4.16E-53*

^*= Statistically Significant at p<0.05.

^†=Beta coefficient estimates represent the change in GrimAA, in years, with each point increase in CVH. P-values for each row represent a two-sided test of whether the estimate is different from zero, corresponding to the beta-value and 95% confidence interval in each row.

All models used GrimAA as the dependent variable, CVH score as the independent variable, and adjusted for field center, sex, race, education, and alcohol consumption. Models of the clinical CVH score additionally adjusted for smoking and physical activity.

CVH components were scored as follows:

For BMI, <25 kg/m2 was ideal, 25–29.9 kg/m2 intermediate, and >30 kg/m2 poor.

For blood pressure, <120/<80 mm Hg without medications was ideal, SBP 120–139 mm Hg or DBP 80–89 mm Hg or successfully treated was intermediate, and SBP >140 or DBP >90 mm Hg poor.

For total cholesterol <200 mg/dL without medication was ideal, 200–239 mg/dL or successfully treated was intermediate, and >240 mg/dL was poor.

For fasting glucose, <100 mg/dL without medication was ideal, 100–125 mg/dL or successfully treated was intermediate, and >126 mg/dL was poor.

For smoking, never smoking or quitting more than 12 months ago was ideal, quitting <12 months ago intermediate, and currently smoking poor.

For physical activity, the top 40% on the physical activity questionnaire was defined as ideal, the second 40% as intermediate, and the lowest 20% as poor.

For diet, the top 40% on the dietary quality questionnaire was defined as ideal, the second 40% as intermediate, and the lowest 20% as poor.