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. Author manuscript; available in PMC: 2022 Feb 19.
Published in final edited form as: Nat Neurosci. 2021 Aug 19;24(10):1429–1440. doi: 10.1038/s41593-021-00912-7

Extended Data Figure 7. Optogenetic inhibition of pPVTD2R–CeA axon terminals in the 2AA task, related to Figure 7.

Extended Data Figure 7.

a, Freezing time during the ITI across training days in both Ctl and Halo groups. n = 9 mice per group. b, Left: Optogenetic inhibition of pPVTD2R–CeA axon terminals gradually reduces freezing time during the the ITI. Right: Normalization to Day 1 for each group. Two-way ANOVA followed by two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli. F(5, 80) = 0.44; group comparisons, Ctl, Day 1 vs Day 6 ***P = 0.0006, Day 2 vs Day 6 *P = 0.011, Day 3 vs Day 6 **P = 0.0074, Day 4 vs Day 6 *P = 0.048; Halo, Day 1 vs Day 6 *P = 0.017. c, Linear regression of the changes in freezing behavior between Test Day 1 and other test sessions as a function of changes in avoidance behavior. All data in figure shown as mean ± s.e.m.