Figure 4 |. Phenome-wide association study in the BioVU biorepository.
−log10 P values for two-sided Z-test of the log of the odds ratio for the genome-wide PRS-CS polygenic score for EXT with 1,335 medical outcomes, estimated with logistic regression in up to 66,915 patients, adjusted for sex, median age in the EHR data, and the first 10 genetic PCs. The dashed line is the Bonferroni-corrected significance threshold; adjusted for the number of tested medical conditions. 84 medical conditions were Bonferroni-significant, while 255 conditions were significant at a false discovery rate less than 0.05. The labels for some conditions were omitted. The complete results, including case-control counts, effect sizes, and standard errors, are reported in Supplementary Table 20.