Table 1.
Summary of seven externalizing-related disorders and behaviors with GWAS summary statistics
| Phenotype (abbreviation) | N | h2 (SE) | λGC | Mean χ2 | Intercept | Ratio | Reference |
|---|---|---|---|---|---|---|---|
| Attention-deficit/hyperactivity disorder (ADHD) | 53,293 | 0.235 (0.015) | 1.253 | 1.297 | 1.034 | 0.113 | 13 |
| Problematic alcohol use (ALCP) | 164,121 | 0.055 (0.004) | 1.149 | 1.174 | 1.013 | 0.073 | 14,15 |
| Lifetime cannabis use (CANN) | 186,875 | 0.066 (0.004) | 1.230 | 1.267 | 1.026 | 0.098 | 16 |
| Age at first sexual intercourse (FSEX)* | 357,187 | 0.115 (0.004) | 1.623 | 1.869 | 1.036 | 0.041 | 17 |
| Number of sexual partners (NSEX) | 336,121 | 0.097 (0.004) | 1.492 | 1.682 | 1.027 | 0.041 | 17 |
| General risk tolerance (RISK) | 426,379 | 0.053 (0.002) | 1.372 | 1.461 | 1.019 | 0.041 | 17 |
| Lifetime smoking initiation (SMOK) | 1,251,809 | 0.078 (0.002) | 2.328 | 3.152 | 1.126 | 0.058 | 18 |
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Notes: The statistics reported in this table were all estimated with LD Score regression12. Heritability (h2) is on the observed scale12. λGC is the median χ2 statistic divided by the expected median of the χ2 distribution with 1 degree of freedom95. Mean χ2 is the average χ2 statistic. Intercept is the estimated LD Score regression intercept. Ratio measures stratification bias, defined as (Intercept – 1) / (Mean χ2 – 1)12.
*
Reverse-coded (see Online Methods).