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. Author manuscript; available in PMC: 2022 Oct 15.
Published in final edited form as: Neuropharmacology. 2021 Aug 17;198:108756. doi: 10.1016/j.neuropharm.2021.108756

Figure 1. Acquisition of Nicotine Self-Administration.

Figure 1.

(A) Timeline of experimental events. (B) Nicotine intake per group. (C) Total nicotine infusions per group. (D) Proportion of active lever presses divided by active + inactive lever presses across the 12 sessions. The dotted line represents the 2:1 active:inactive lever press criterion. (E) OVX vehicle females weighed significantly more than the other three groups across the nicotine self-administration sessions. OVX-E2 and OVX-EE groups weighed significantly more than sham vehicle females. SEM = standard error of the mean; OVX = ovariectomized; JVC = jugular vein catheter; g = grams.