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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Circ Res. 2021 Aug 13;129(8):e166–e182. doi: 10.1161/CIRCRESAHA.121.319104

Fig 6. Top-ranking FAAs, including spironolactone (Spi), pravastatin (Pra), minoxidil (Mino) and rapamycin (Rapa), exerted therapeutic effects in a mouse AIC model in a time-dependent fashion.

Fig 6.

(A) Schematics of the experimental procedure for drug administration in the early phase of the mouse AIC model. (B to D) Echocardiography was performed to evaluate cardiac functions. (n=5) (E) Schematics of the experimental procedure for drug administration to the AIC model mice in the late phase. (F to H) Echocardiography was performed to evaluate cardiac functions. (n=5) (I and J) All four drugs attenuated the increase in serum LDH and CKMB. (n=8). (K) All four drugs reversed body weight loss in the AIC model mice. (n=10). One-way ANOVA followed by post hoc Tukey’s test was used. Log-rank test was used in (K) for comparisons with the model group. We applied a 0.5% aqueous solution of sodium carboxymethylcellulose (CMC) as a vehicle.