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Exemplary staining with HE and anti-FAP α monoclonal antibody of a pleural biopsy due to breast cancer. The pleural metastasis, located in the mediastinum, presented a SUVmax of 7.46 in the FAPI-PET/CT 8 months prior to the biopsy (a). The stroma demonstrated markedly strong FAP expression (d), and high-to-moderate expression was observed in neoplastic cells. The depicted cell clusters (b, c) most likely represent tumorous cell nests and demonstrated strong FAP expression as well
