Table 1.

Hypoxia-inducible factor stabilizers under development^a

Variable	Daprodustat	Desidustat	Enarodustat	Molidusat	Roxadustat	Vadadustat
Investigational designation	GSK1278863	ZYAN1	JTZ-951	BAY 85-3934	FG-4592 ASP1517 AZD9941	AKB-6548 MT-6548
PHD isoform specificity	PHD2 > PHD1 > PHD3	Not reported	PHD3 > PHD2 > PHD1	PHD2>PHD1>PHD3	PHD1 > PHD3 > PHD2	PHD2 > PHD1 > PHD3
Effective half-life (h)	2.25	7.0–11.4	8.96	4–10	12–15	4.9–9.1
Dosing interval	Daily	Daily	Daily	Daily	3 times weekly	Daily

PHD, prolyl hydroxylase domain.

^aAdapted from Sanghani and Haase³⁴ and Haase.³⁵