Table 3.

Odds ratios and 95% confidence interval for cardiovascular death associated with levels and composition of the circulating microbiome in hemodialysis patients

Characteristics	Model 1		Model 2		Model 3
	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
16S rRNAa, per log10 ng/μl	0.28 (0.005–15.1)	0.53	0.13 (0.001–16.1)	0.40	0.38 (0.002–85.7)	0.73
Shannon Index, per unit	0.75 (0.21–2.71)	0.66	1.09 (0.24–4.87)	0.91	0.92 (0.17–4.92)	0.71
Actinobacteria, per percent	1.11 (0.99–1.22)	0.053	1.14 (0.99–1.30)	0.067	1.12 (0.98–1.29)	0.086
Proteobacteria, per percent	0.92 (0.84–1.01)	0.095	0.90 (0.81–1.01)	0.080	0.88 (0.76–1.02)	0.099

All models matched for age, sex, race, and dialysis vintage. Model 1 is unadjusted: model 2 is adjusted for age and dialysis vintage to account for residual imbalance; and model 3 is adjusted for the variables in model 2 plus vascular access type.

CI, confidence interval; OR, odds ratio; rRNA, ribosomal RNA.

^aValues were log transformed.