Table 2.
Comparison of histologic features of patients with and without C3 deposition
| Variable | All (N = 142) | C3 positive (n = 56) | C3 negative (n = 86) | P value |
|---|---|---|---|---|
| No. glomeruli | 21 (14–33) | 20 (16–32) | 22 (14–33) | 0.79 |
| % Normal glomeruli | 37.5 (17.2–61.2) | 37.1 (17.3–57.1) | 38.9 (17.1–64.4) | 0.45 |
| % Global sclerosis | 23.1 (9.8–43.9) | 23.2 (11.1–49.7) | 22.6 (8.3–41.6) | 0.45 |
| % Cellular crescents | 23.6 (8.3–43.6) | 21.7 (7.4–43.0) | 24.7 (8.9–44.2) | 0.73 |
| % Fibrous crescents | 0.0 (0.0–5.3) | 0.0 (0.0–5.5) | 0.0 (0.0–5.5) | 0.65 |
| IF/TA, n (%) | 0.82 | |||
| <10% | 8 (5.6) | 3 (5.4) | 5 (5.8) | — |
| 10%–25% | 33 (23.2) | 14 (25.0) | 19 (22.1) | — |
| 26%–50% | 57 (40.1) | 22 (39.3) | 35 (40.7) | — |
| >50% | 44 (31.0) | 17 (30.4) | 27 (31.4) | — |
| ANCA-GN classification, n (%) | 0.52 | |||
| Focal | 50 (35.2) | 19 (33.9) | 31 (36.0) | — |
| Crescentic | 25 (17.6) | 9 (16.1) | 16 (18.6) | — |
| Mixed | 40 (28.2) | 14 (25.0) | 26 (30.2) | — |
| Sclerotic | 27 (19.0) | 14 (25.0) | 13 (15.1) | — |
| Immunofluorescence, n (%) | ||||
| IgM | 46 (32.4) | 31 (55.4) | 15 (17.4) | <0.001 |
| IgG | 22 (15.5) | 15 (26.8) | 7 (8.1) | 0.003 |
| IgA | 20 (14.1) | 10 (17.9) | 10 (11.6) | 0.30 |
| C1q | 18 (12.7) | 12 (21.4) | 6 (7.0) | 0.01 |
| EDD, n/N (%)a | 15/127 (11.8) | 9/48 (18.8) | 6/79 (7.6) | 0.06 |
ANCA-GN, antineutrophil cytoplasmic antibody–associated glomerulonephritis; EDD, electron-dense deposit; IF/TA, interstitial fibrosis and/or tubular atrophy; IQR, interquartile range.
Values are presented as medians and IQRs or numbers with percentages in parentheses.
a
A total of 15 missing values.