Table 3.
Mean Z-scores of the intervention group and control group on cognitive performance and PROs per time-point
| Intervention group | Control group | |||||
|---|---|---|---|---|---|---|
| T3 (n = 23) | T6 (n = 23) | T12 (n = 20) | T3 (n = 26) | T6 (n = 26) | T12 (n = 25) | |
| Cognitive performance outcomes | ||||||
| Verbal Memory | − 0.41 | − 0.10 | 0.09 | − 0.68 | − 0.64 | − 0.68 |
| Visual Memory | 0.13 | 0.09 | − 0.07 | − 0.37 | − 0.45 | − 0.56 |
| Processing Speed | − 0.36 | − 0.07 | 0.09 | − 0.60 | − 0.51 | 0.00 |
| Psychomotor Speed | − 0.22 | − 0.28 | 0.12 | − 0.36 | − 0.38 | − 0.27 |
| Reaction Time | − 0.55 | − 0.44 | − 0.13 | − 1.36 | − 1.32 | − 1.46 |
| Complex Attention | − 1.54 | − 0.35 | 0.00 | − 1.22 | − 0.75 | − 0.51 |
| Cognitive Flexibility | − 0.98 | − 0.45 | − 0.18 | − 1.19 | − 0.77 | − 0.57 |
| Working Memory | − 0.06 | 0.09 | 0.34 | − 0.05 | 0.05 | 0.15 |
| Verbal Fluency | − 0.34 | − 0.33 | − 0.05 | − 0.60 | − 0.28 | − 0.25 |
| Impaired on ≥ 1 performance-based outcomes (n; %) | 16/23 (70) | 15/23 (65) | 7/20 (35) | 19/26 (73) | 18/26 (69) | 17/25 (68) |
| Patient Reported Outcomes | ||||||
| Cognitive complaints (CFQ) | − 0.43 | − 0.07 | 0.23 | 0.12 | 0.23 | 0.08 |
| Behavioral regulation (BRIEF-A) | − 0.13 | 0.19 | – | 0.10 | 0.26 | – |
| Metacognition (BRIEF-A) | − 0.66 | − 0.27 | – | − 0.41 | − 0.24 | – |
| Physical fatigue (MFI) | − 0.63 | − 0.52 | − 0.29 | − 0.66 | − 0.81 | − 0.46 |
| Mental fatigue (MFI) | − 0.96 | − 0.69 | − 0.42 | − 1.04 | − 0.74 | − 0.63 |
| Anxiety symptoms (HADS) | 0.12 | 0.26 | 0.19 | 0.18 | 0.37 | 0.38 |
| Depressive symptoms (HADS) | − 0.02 | − 0.09 | 0.26 | 0.19 | 0.13 | 0.11 |
| Impaired on ≥ 1 PRO (n; %) | 14/23 (61) | 9/23 (39) | 5/20 (25) | 18/26 (69) | 14/26 (54) | 13/25 (52) |
Higher mean scores indicate better outcomes
CFQ cognitive failures questionnaire, BRIEF-A behaviour rating inventory of executive function, MFI multidimensional fatigue inventory, HADS hospital anxiety and depression scale