Table 4. Sensitivity, Specificity, Accuracy, PPV and NPV of HCC Under Various Adjustment of Major and Ancillary Features in LI-RADS v2018.
| Sensitivity | Specificity | PPV | NPV | Accuracy | P † | P ‡ | ||
|---|---|---|---|---|---|---|---|---|
| LI-RADS v2018 | ||||||||
| LR-5 | 73.2 (451/616) [69.5, 76.7] |
98.2 (390/397) [96.4, 99.3] |
98.5 (451/458) [96.9, 99.3] |
70.3 (390/555) [67.5, 72.9] |
83.0 (841/1013) [80.6, 85.3] |
|||
| Fat- in-nodule as an additional major feature | ||||||||
| LR-5 | 73.9 (455/616) [70.2, 77.3] |
98.2 (390/397) [96.4, 99.3] |
98.5 (455/462) [96.9, 99.3] |
70.8 (390/551) [68.0, 73.5] |
83.4 (845/1013) [81.0, 85.7] |
0.125 | > 0.999 | |
| Fat-in-nodule replaces threshold growth as major feature* | ||||||||
| LR-5 | 73.9 (455/616) [70.2, 77.3] |
98.5 (391/397) [96.7, 99.4] |
98.7 (455/461) [97.2, 99.4] |
70.8 (391/552) [68.0, 73.5] |
83.5 (846/1013) [81.1, 85.8] |
0.289 | > 0.999 | |
Data are percentages with the number of lesions in parentheses. Numbers in brackets are the 95% confidence intervals. *Threshold growth was considered as an ancillary feature, †p value after comparing sensitivity to sensitivity of original LR-5 using McNemar's test, ‡p value after comparing specificity to specificity of original LR-5 using McNemar's test. HCC = hepatocellular carcinoma, LI-RADS = Liver Imaging Reporting and Data Systems, NPV = negative predictive value, PPV = positive predictive value