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. 2021 Mar 27;110(10):1564–1573. doi: 10.1007/s00392-021-01846-7

Table 1.

Genetic variants associated with self-reported physical activity (PA), accelerometer-assessed PA, vigorous PA and sedentary bevahior

SNP Chr Position (hg38) EA OA EAF beta se P value R2 F statistic
Self-reported MVPA (based on a GWAS by Klimentidis et al. [23])
 rs2942127 1 204450939 G A 0.175 0.016 0.003 3.30E−08 0.00008 30.522
 rs1974771 2 54051406 G A 0.9 -0.021 0.004 6.60E−09 0.00009 33.654
 rs2114286 3 41152792 A G 0.466 − 0.012 0.002 3.30E−08 0.00008 30.501
 rs877483 3 53812714 T C 0.433 0.012 0.002 4.00E−08 0.00008 30.132
 rs2035562 3 85007370 A G 0.328 − 0.014 0.002 3.90E−09 0.00009 34.687
 rs1972763 4 158939411 C T 0.342 0.013 0.002 3.30E−08 0.00008 30.526
 rs77742115 5 18330315 T C 0.862 − 0.018 0.003 9.60E−09 0.00009 32.922
 rs2854277 6 32660307 C T 0.917 0.032 0.005 2.60E−10 0.00011 39.959
 rs1186721 7 34934990 G A 0.684 − 0.013 0.002 4.40E−08 0.00008 29.984
 rs921915 7 50188985 T C 0.412 − 0.014 0.002 5.70E−10 0.0001 38.436
 rs1043595 7 128769958 G A 0.717 0.014 0.002 4.30E−09 0.00009 34.481
 rs7804463 7 133762898 T C 0.53 0.015 0.002 1.20E−11 0.00012 45.987
 rs2988004 9 37044391 T G 0.558 − 0.013 0.002 4.10E−09 0.00009 34.579
 rs7326482 13 53463668 G T 0.385 − 0.013 0.002 1.60E−08 0.00008 31.915
 rs10145335 14 98081411 G A 0.749 − 0.014 0.003 2.70E−08 0.00008 30.878
 rs12912808 15 94748994 C T 0.851 0.018 0.003 1.70E−08 0.00008 31.852
 rs1921981 21 41050620 G A 0.674 0.013 0.002 3.80E−08 0.00008 30.224
Accelerometer assessed average acceleration (based on a GWAS by Klimentidis et al. [23])
 rs34517439 1 77984833 C A 0.879 0.308 0.056 4.40E−08 0.00033 29.972
 rs6775319 3 18717009 A T 0.271 0.225 0.041 3.50E−08 0.00033 30.43
 rs9293503 5 88653144 T C 0.888 0.329 0.059 2.10E−08 0.00034 31.42
 rs12522261 5 152675265 G A 0.657 0.211 0.038 3.90E−08 0.00033 30.207
 rs11012732 10 21541175 A G 0.668 0.225 0.039 5.40E−09 0.00037 34.036
 rs148193266 11 104657953 A C 0.957 − 0.51 0.092 3.10E−08 0.00034 30.67
 rs59499656 18 43188344 A T 0.656 − 0.228 0.038 2.40E−09 0.00039 35.597
Fraction accelerations > 425 milli-gravities (based on a GWAS by Klimentidis et al. [23])
 rs1856329 1 219766281 A C 0.801 0.027 0.005 9.00E−08 0.00032 28.569
 rs6433478 2 174376754 T C 0.457 − 0.024 0.004 1.20E−08 0.00036 32.465
 rs62443625 7 39013531 T C 0.767 − 0.026 0.005 1.40E−07 0.00031 27.683
 rs72633364 8 34329370 G A 0.711 − 0.023 0.005 4.10E−07 0.00028 25.635
 rs4754194 11 107219461 C T 0.773 − 0.025 0.005 2.40E−07 0.00029 26.642
 rs743580 15 74035775 A G 0.51 0.025 0.004 1.30E−09 0.00041 36.764
 rs1668835 18 24898988 T A 0.688 − 0.023 0.004 3.10E−07 0.00029 26.184
Sedentary behaviour (based on a GWAS by Doherty et al. [22])
 rs61776614 1 2234967 C T 0.925 0.05 0.009 3.90E−08 0.00033 30.182
 rs1858242 3 68477984 A G 0.259 0.031 0.005 3.80E−09 0.00038 34.745
 rs26579 5 88689478 G C 0.415 0.028 0.005 2.60E−09 0.00039 35.446
 rs25981 5 107487207 G C 0.531 0.028 0.005 2.70E−09 0.00039 35.366
 rs6870096 5 152566250 C G 0.321 − 0.028 0.005 2.40E−08 0.00034 31.149
 rs34858520 7 72258898 A G 0.558 0.028 0.005 4.50E−09 0.00038 34.402

SNP single nucleotide polymorphism, Chr. chromosome, hg38 human genome assembly 38, EA effect allele, OA other allele, EAF effect allele frequency, beta beta estimate, se standard error, MVPA moderate to vigorous physical activity