Table 2.

Mendelian randomization estimates between self-reported moderate-to-vigorous physical activity identified by Klimentidis et al. [23] and coronary artery disease, myocardial infarction, and ischemic stroke

Method	N SNPs	ORa	95% CI	P value
Coronary artery disease
Inverse variance weighted	17	1.03	(0.71–1.50)	0.875
Weighted median	17	0.94	(0.57–1.54)	0.800
MR Egger	17	1.81	(0.31–10.61)	0.512
MR PRESSO	17	1.03	(0.71–1.49)	0.877
Myocardial infarction
Inverse variance weighted	17	1.16	(0.74–1.80)	0.519
Weighted median	17	1.28	(0.74–2.23)	0.375
MR Egger	17	1.57	(0.19–12.97)	0.676
MR PRESSO	17	1.16	(0.74–1.80)	0.527
Ischemic stroke
Inverse variance weighted	17	1.16	(0.80–1.67)	0.436
Weighted median	17	1.15	(0.71–1.87)	0.565
MR Egger	17	1.51	(0.26–8.74)	0.649
MR PRESSO	17	1.16	(0.86–1.55)	0.340

MR PRESSO MR Pleiotropy RESidual Sum and Outlie, CI confidence interval, MET metabolic equivalent tasks

^aOR (odds ratio) per increase in MET/h per week for self-reported physical activity