Table 3.
Mendelian randomization estimates between accelerometer-derived average accelerations identified by Klimentidis et al. [23] in relation to coronary artery disease, myocardial infarction, and ischemic stroke
| Method | N SNPs | ORa | 95% CI | P value |
|---|---|---|---|---|
| Coronary artery disease | ||||
| Inverse variance weighted | 7 | 1.01 | (0.96–1.06) | 0.802 |
| Weighted median | 7 | 0.99 | (0.95–1.04) | 0.722 |
| MR Egger | 7 | 1.14 | (0.94–1.38) | 0.198 |
| MR PRESSO | 7 | 1.01 | (0.96–1.06) | 0.809 |
| Myocardial infarction | ||||
| Inverse variance weighted | 7 | 0.99 | (0.95–1.04) | 0.748 |
| Weighted median | 7 | 0.99 | (0.94–1.05) | 0.794 |
| MR Egger | 7 | 1.08 | (0.88–1.32) | 0.476 |
| MR PRESSO | 7 | 0.99 | (0.95–1.04) | 0.752 |
| Ischemic stroke | ||||
| Inverse variance weighted | 7 | 0.98 | (0.92–1.05) | 0.515 |
| Weighted median | 7 | 0.97 | (0.91–1.03) | 0.312 |
| MR Egger | 7 | 1.11 | (0.84–1.46) | 0.472 |
| MR PRESSO | 6 | 0.96 | (0.90–1.02) | 0.213 |
MR PRESSO MR Pleiotropy RESidual Sum and Outlier, CI confidence interval
aOR (odds ratio) per increase in milligravities for accelerometer derived physical activity