Table 4.

Mendelian randomization estimates between fraction acceleration > 425 milli-gravities identified by Klimentidis et al. [23] in relation to coronary artery disease, myocardial infarction, and ischemic stroke

Method	N SNPs	ORa	95% CI	P value
Coronary artery disease
Inverse variance weighted	7	0.77	(0.48–1.25)	0.293
Weighted median	7	0.86	(0.52–1.43)	0.564
MR Egger	7	23.42	(0.01–113,590)	0.466
MR PRESSO	7	0.77	(0.48–1.25)	0.334
Myocardial infarction
Inverse variance weighted	7	0.75	(0.48–1.16)	0.188
Weighted median	7	0.60	(0.35–1.02)	0.057
MR Egger	7	22.35	(0.01–49,622)	0.429
MR PRESSO	7	0.75	(0.48–1.16)	0.236
Ischemic stroke
Inverse variance weighted	7	0.77	(0.52–1.14)	0.192
Weighted median	7	0.83	(0.52–1.32)	0.437
MR Egger	7	0.34	(0–559.72)	0.773
MR PRESSO	7	0.77	(0.52–1.14)	0.240

MR PRESSO MR Pleiotropy RESidual Sum and Outlier, CI confidence interval

^aOR (odds ratio) for engaging in vigorous physical activity (≥ 425 milli-gravities)