Table 5.

Mendelian randomization estimates between sedentary behavior identified by Doherty et al. [22] in relation to coronary artery disease, myocardial infarction, and ischemic stroke

Method	N SNPs	ORa	95% CI	P value
Coronary artery disease
Inverse variance weighted	6	0.91	(0.56–1.49)	0.709
Weighted median	6	0.92	(0.63–1.35)	0.662
MR Egger	6	30.61	(2.25–417)	0.010
MR PRESSO	5	1.10	(0.73–1.66)	0.678
Myocardial infarction
Inverse variance weighted	6	0.96	(0.59–1.56)	0.855
Weighted median	6	1.04	(0.68–1.60)	0.856
MR Egger	6	21.87	(1.07–446)	0.045
MR PRESSO	6	0.96	(0.59–1.56)	0.862
Ischemic stroke
Inverse variance weighted	6	1.06	(0.75–1.48)	0.748
Weighted median	6	1.11	(0.75–1.66)	0.599
MR Egger	6	2.07	(0.20–21.36)	0.541
MR PRESSO	6	1.06	(0.75–1.48)	0.761

MR PRESSO MR Pleiotropy RESidual Sum and Outlier

^aOR (odds ratio) for displaying sedentary behavior (energy expenditure ≤ 1.5MET/h)