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. 2021 Jul 9;147(11):3211–3224. doi: 10.1007/s00432-021-03722-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Sensitivity of palbociclib-resistant sublines to other molecular-targeted agents. The sensitivity of wild-type (wt) and palbociclib-resistant sublines (MCF7-P1, MCF7-P2, and T47D-PR) to abemaciclib, everolimus, and dinaciclib was determined using the WST assay. The black lines indicate wild-type cells, and the gray lines with markers (▲, ■, ◆) indicate palbociclib-resistant cells. Error bars represent the standard error of the value obtained from triplicate experiments. a Sensitivity to the CDK4/6 inhibitor, abemaciclib. b Sensitivity to the mTOR inhibitor, everolimus. c Sensitivity to the CDK1/2/5/9 inhibitor, dinaciclib