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. 2021 Jul 9;147(11):3211–3224. doi: 10.1007/s00432-021-03722-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Sensitivity of palbociclib-resistant sublines to the combination of palbociclib and fulvestrant. The sensitivity of wild-type cells (a and d), palbociclib-resistant sublines maintained with palbociclib for long-term (b, T47D-PR-L; e, MCF7-P1-L; g, MCF7-P2-L) and palbociclib-resistant sublines deprived palbociclib for more than 3 months (c, T47D-PR-RE; f, MCF7-P1-RE; h, MCF7-P2-RE) to the combination therapy with palbociclib and fulvestrant was determined using the WST assay. The black lines indicate the cells without fulvestrant. The gray lines with markers (▲, ■, ◆) indicate the cells treated with palbociclib in combination with 100 pM (●), 100 nM (▲), and 1 µM (■) of fulvestrant. Error bars represent the standard error of the value obtained from triplicate experiments