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. 2021 Aug 13;48(12):4042–4053. doi: 10.1007/s00259-021-05501-1

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© The Author(s) 2021, corrected publication 2022

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Fig. 7 — Examples of PSMA expression on immunohistochemistry (IHC) and ⁶⁸Ga-PSMA-PET results. (A) Illustration of a prostate carcinoma with a strong homogenous PSMA expression (left) and a high SUV_max located in the anterior right part of the gland. (B) Example of a prostate carcinoma (circled) showing almost no PSMA IHC staining (80% negative tumour area) and also lacking PSMA-PET positivity in the corresponding area. (C) is a case that shows a predominantly PSMA IHC-positive prostate carcinoma (only 5% completely PSMA-negative glands) with a low PSMA-PET positivity (SUV_max 4). Note the small diameter of this carcinomatous focus (8.7 mm). (D) Conversely, this carcinoma with a diameter of 22 mm shows a high PSMA-PET positivity (SUV_max 13.33) despite a heterogenous, largely lacking PSMA IHC expression (almost 70% negative areas). Scale bar 5 mm