Table 3.
Cytoplasmic and nuclear HMGA2 expression in malignant and non-malignant ducts
| (a) | Cytoplasm | Nuclei | ||
|---|---|---|---|---|
| n | % | n | % | |
| Positive tumor cells | ||||
| 0% | 14 | 13.2 | 2 | 1.9 |
| < 10% | 0 | 0.0 | 2 | 1.9 |
| 11—50% | 8 | 7.5 | 21 | 19.8 |
| 51—80% | 22 | 20.8 | 22 | 20.8 |
| > 80% | 62 | 58.5 | 59 | 55.7 |
| Staining intensity | ||||
| Negative | 14 | 13.2 | 2 | 1.9 |
| Weakly positive | 88 | 83.0 | 42 | 39.6 |
| Moderately positive | 4 | 3.8 | 35 | 33.0 |
| Strongly positive > 80% | 0 | 0.0 | 27 | 25.5 |
| Sum score | ||||
| 0 | 14 | 13.2 | 2 | 1.9 |
| 2 | 0 | 0.0 | 1 | 0.9 |
| 3–4 | 30 | 28.3 | 25 | 23.6 |
| 5–6 | 62 | 58.5 | 57 | 53.7 |
| 7 | 0 | 0.0 | 21 | 19.8 |
| (b) | Cytoplasm | Nuclei | ||||||
|---|---|---|---|---|---|---|---|---|
| Tumor | Non-malignant | Tumor | Non-malignant | |||||
| Staining intensity | n | % | n | % | n | % | n | % |
| Negative | 5 | 17.9 | 8 | 28.6 | 1 | 3.6 | 5 | 17.9 |
| Weakly positive | 23 | 82.1 | 18 | 64.3 | 13 | 46.4 | 14 | 50.0 |
| Moderately positive | 0 | 0.0 | 2 | 7.1 | 7 | 25.0 | 9 | 32.1 |
| Strongly positive | 0 | 0.0 | 0 | 0.0 | 7 | 25.0 | 0 | 0.0 |
| Staining pattern: tumor vs. non-malignant |
No difference ns, p = 0.5 |
** p = 0.003 |
||||||
(a) number of positive cells, staining intensity and corresponding sum score are shown for cytoplasm and nucleus separately. Additionally, particular staining intensity in relation to histologic specification (tumor vs. peritumoral non-malignant) and for cytoplasmic vs. nuclear staining are provided in (b)