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. 2021 Jul 22;147(11):3299–3312. doi: 10.1007/s00432-021-03743-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — MSI-1 is associated with survival outcomes in breast cancer patients. Across all breast cancer patients (left column), higher than median MSI-1 expression results in decreased distant metastasis-free survival (DMFS, hazard ratio [HR] = 1.16, p = 0.0016) and disease-free survival (DFS, HR = 1.07, p = 0.042) and tends to decrease overall survival (OS, HR = 1.06, p = 0.22). Similarly, in the estrogen receptor (ER)-positive group (right column), greater than median MSI-1 expression is associated with decreased DMFS (HR = 1.15, p = 0.016), DFS (HR = 1.09, p = 0.038) and OS (HR = 1.12, p = 0.038). Analyses (visualization and log-rank tests) were performed using the bc-GenExMiner tool (Jézéquel et al. 2012)