Table 2.
Real-world treatment adherence based on the number of antihypertensive pills
| Variables | 1 pill | 2 pills | 3 pills | P value |
|---|---|---|---|---|
| N. | 10551 | 2500 | 145 | |
| Age (mean (SD)) | 73.14 (7.58) | 73.31 (7.06) | 76.40 (4.76) | <0.001 |
| Men (%) | 4721 (44.7) | 1062 (42.5) | 87 (60.0) | <0.001 |
| Hospitalized in the past year (%) | 1695 (16.1) | 458 (18.3) | 24 (16.6) | 0.039 |
| Adherence (mean (SD)) | 73.44 (15.75) | 52.95 (11.61) | 38.04 (7.79) | <0.001 |
| Fully adherent participants (%) | 5643 (53.5) | 78 (3.1) | 0 (0.0) | <0.001 |
| BP measurements (mean (SD)) | 31.97 (20.41) | 36.76 (23.55) | 36.28 (18.36) | <0.001 |
| Systolic BP, mmHg (mean (SD)) | 132.15 (14.30) | 134.00 (14.31) | 132.52 (14.98) | <0.001 |
| Diastolic BP, mmHg (mean (SD)) | 75.95 (8.12) | 76.18 (8.15) | 76.21 (8.56) | 0.438 |
| PP, mmHg (mean (SD)) | 56.21 (12.53) | 57.83 (12.33) | 56.30 (13.42) | <0.001 |
| Controlled hypertension (%) | 7284 (69.0) | 1641 (65.6) | 102 (70.3) | 0.004 |
| No fixed combinations (%) | 7795 (73.9) | 1870 (74.8) | 86 (59.3) | <0.001 |
| Fixed-dose double combinations (%) | <0.001 | |||
| None | 7957 (75.4) | 1878 (75.1) | 86 (59.3) | |
| 1 | 2594 (24.6) | 578 (23.1) | 49 (33.8) | |
| 2 | 0 (0.0) | 44 (1.8) | 10 (6.9) | |
| Fixed-dose triple combination (%) | 162 (1.5) | 10 (0.4) | 1 (0.7) | <0.001 |
| Active ingredients in therapy (mean (SD)) | 1.28 (0.48) | 2.27 (0.50) | 3.49 (0.66) | <0.001 |
| ACE inhibitors (%) | <0.001 | |||
| 0 | 7313 (69.3) | 1494 (59.8) | 50 (34.5) | |
| 1 | 3238 (30.7) | 863 (34.5) | 62 (42.8) | |
| 2 | 0 (0.0) | 143 (5.7) | 29 (20.0) | |
| 3 | 0 (0.0) | 0 (0.0) | 4 (2.8) | |
| Beta blockers (%) | <0.001 | |||
| 0 | 8345 (79.1) | 1577 (63.1) | 45 (31.0) | |
| 1 | 2206 (20.9) | 822 (32.9) | 61 (42.1) | |
| 2 | 0 (0.0) | 101 (4.0) | 37 (25.5) | |
| 3 | 0 (0.0) | 0 (0.0) | 2 (1.4) | |
| Calcium channel blockers (%) | <0.001 | |||
| 0 | 8090 (76.7) | 1541 (61.6) | 86 (59.3) | |
| 1 | 2461 (23.3) | 847 (33.9) | 52 (35.9) | |
| 2 | 0 (0.0) | 112 (4.5) | 7 (4.8) | |
| Diuretics (%) | <0.001 | |||
| 0 | 7951 (75.4) | 1186 (47.4) | 62 (42.8) | |
| 1 | 2511 (23.8) | 1097 (43.9) | 62 (42.8) | |
| 2 | 89 (0.8) | 217 (8.7) | 20 (13.8) | |
| 3 | 0 (0.0) | 0 (0.0) | 1 (0.7) | |
| Angiotensin II receptor blockers (%) | <0.001 | |||
| 0 | 7676 (72.8) | 1654 (66.2) | 93 (64.1) | |
| 1 | 2875 (27.2) | 781 (31.2) | 42 (29.0) | |
| 2 | 0 (0.0) | 65 (2.6) | 10 (6.9) |
BP blood pressure, PP pulse pressure, ACE angiotensin converting enzyme