Table 3.
Real-world treatment adherence and BP profile based on fixed-dose combinations versus free combinations of two active ingredients
| One fixed-dose double combination | Free combination of 2 active ingredients | P value | |
|---|---|---|---|
| N | 2594 | 1878 | |
| Age (mean (SD)) | 72.72 (7.17) | 73.28 (7.11) | 0.009 |
| Men (%) | 1137 (43.8) | 795 (42.3) | 0.333 |
| Adherence (mean (SD)) | 78.26 (14.34) | 52.49 (11.66) | <0.001 |
| Fully adherent participants (%) | 1776 (68.5) | 36 (1.9) | <0.001 |
| BP measurements (mean (SD)) | 33.15 (20.54) | 35.73 (23.10) | <0.001 |
| Systolic BP, mmHg (mean (SD)) | 131.91 (14.09) | 133.91 (14.54) | <0.001 |
| Diastolic BP, mmHg (mean (SD)) | 75.70 (7.71) | 76.36 (8.08) | 0.006 |
| PP, mmHg (mean (SD)) | 56.23 (12.60) | 57.57 (12.43) | <0.001 |
| Controlled hypertension (%) | 1816 (70.0) | 1224 (65.2) | 0.001 |
| Antihypertensive pills (mean (SD)) | 1.00 (0.00) | 2.00 (0.00) | <0.001 |
BP blood pressure, PP pulse pressure