Table 4.
Cox proportional-hazards models
| Variables | Model 1a | Model 2a | Model 3a |
|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| Age groups | |||
| 18–49 | Reference | Reference | Reference |
| 50–59 | 1.52 (1.45–1.58) | 1.57 (1.49–1.66) | 1.55 (1.47–1.64) |
| 60–69 | 2.00 (1.92–2.08) | 2.03 (1.93–2.13) | 1.99 (1.89–2.10) |
| 70–79 | 3.05 (2.93–3.17) | 3.10 (2.95–3.26) | 2.94 (2.79–3.10) |
| ≥ 80 | 4.86 (4.62–5.12) | 4.69 (4.37–5.03) | 4.36 (4.05–4.70) |
| Men | Reference | Reference | Reference |
| Women | 0.94 (0.92–0.96) | 0.93 (0.90–0.95) | 0.92 (0.89–0.95) |
| Period 1999–2005 | Reference | Reference | Reference |
| Period 2006–2010 | 0.85 (0.83–0.87) | 0.87 (0.84–0.91) | 0.96 (0.92–0.99) |
| Period 2011–2014 | 0.82 (0.80–0.85) | 0.86 (0.83–0.90) | 1.00 (0.96–1.04) |
| Surgery, No | – | Reference | Reference |
| Surgery, Yes | – | 0.70 (0.68–0.73) | 0.74 (0.71–0.77) |
| Radiotherapy, No | – | Reference | Reference |
| Radiotherapy, Yes | – | 0.72 (0.70–0.74) | 0.87 (0.84–0.91) |
| Chemotherapy, No | – | – | Reference |
| Chemotherapy, Yes | – | – | 0.70 (0.67–0.72) |
aModel 1 is age and sex adjusted, Model 2 is Model 1 + surgery and radiotherapy, Model 3 is Model 2 + chemotherapy. Abbreviations: HR – hazard ratio; CI – confidence interval