Table 2.
Significant correlations between vascular and bone biomarkers.
| Vascular biomarker | Bone biomarker | R value | p value |
|---|---|---|---|
| Vascular imaging vs bone imaging | |||
| IMT-0 | QCTTOTBMD-12 | − 0.314 | 0.046 |
| IMT-0 | QCTTRABBMD-0 | − 0.355 | 0.023 |
| IMT-6 | QCTTOTBMD-0 | − 0.395 | 0.011 |
| IMT-6 | QCTTOTBMD-12 | − 0.387 | 0.012 |
| IMT-6 | QCTTRABBMD-0 | − 0.496 | 0.001 |
| IMT-6 | QCTTRABBMD-12 | − 0.339 | 0.030 |
| IMT-12 | QCTTOTBMD-0 | − 0.437 | 0.004 |
| IMT-12 | QCTTOTBMD-12 | − 0.543 | < 0.001 |
| IMT-12 | QCTTRABBMD-0 | − 0.366 | 0.019 |
| IMT-12 | QCTTRABBMD-12 | − 0.442 | 0.004 |
| PWV-12 | QCTTOTBMD-12 | − 0.333 | 0.033 |
| Vascular imaging vs bone laboratory biomarker | |||
| FMD-0 | OPG-0 | 0.343 | 0.041 |
| FMD-6 | OPG-6 | 0.460 | 0.002 |
| FMD-6 | OPG-0 | 0.503 | 0.001 |
| IMT-0 | SOST-0 | 0.346 | 0.039 |
| IMT-12 | SOST-12 | 0.347 | 0.023 |
| IMT-12 | OC-12 | − 0.307 | 0.032 |
| IMT-12 | P1NP-12 | − 0.293 | 0.041 |
| IMT-12 | VITD3-0 | − 0.337 | 0.018 |
| PWV-6 | PTH-6 | 0.306 | 0.036 |
| PWV-12 | CATHK-0 | 0.376 | 0.013 |
| PWV-12 | CATHK-12 | 0.352 | 0.021 |
| Vascular laboratory biomarker vs bone imaging | |||
| PDGFBB-0 | DEXFEMBMD-0 | 0.385 | 0.043 |
| PDGFBB-0 | DEXFEMBMD-12 | 0.434 | 0.021 |
| Vascular laboratory biomarker vs bone laboratory biomarker | |||
| ANG1-0 | DKK1-0 | 0.669 | < 0.001 |
| ANG1-6 | DKK1-6 | 0.513 | 0.039 |
| ANG2-0 | DKK1-0 | 0.467 | 0.018 |
| ANG2-0 | OPG-0 | 0.486 | 0.014 |
| ANG2-6 | OPG-6 | 0.486 | 0.014 |
| ANG2-6 | RANKL-6 | − 0.440 | 0.028 |
| ANG2-12 | OPG-12 | 0.698 | < 0.001 |
| PDGFBB-0 | DKK1-0 | 0.545 | 0.005 |
| PDGFBB-12 | DKK1-12 | 0.516 | 0.008 |
| TSP1-0 | OPG-0 | 0.589 | 0.002 |
| TSP1-0 | SOST-0 | 0.466 | 0.019 |
| TSP1-0 | SOST-12 | 0.457 | 0.022 |
| BNP-0 | CTX-0 | 0.289 | 0.048 |
| BNP-12 | CTX-0 | 0.374 | 0.010 |
| BNP-12 | OC-12 | 0.321 | 0.028 |
ANG1 angiopoietin 1, ANG2 angiopoietin 2, BMD bone mineral density, BNP brain-type natriuretic peptide, CATHK cathepsin K, CTX C-terminal telopeptide, DEXFEMBMD DXA femoral neck BMD, DKK1 Dickkopf-1, FMD flow-mediated vasodilation, IMT carotid intima-media thickness, OC osteocalcin, OPG osteoprotegerin, PDGFBB platelet-derived growth factor BB, P1NP procollagen type I N-propeptide, PTH parathyroid hormone, PWV pulse-wave velocity, QCTTOTBMD QCT total BMD, QCTTRABBMD QCT trabecular BMD; RANKL Receptor Activator of Nuclear κB Ligand, SOST sclerostin, TSP1 thrombospondin 1, VITD3 vitamin D3.