Table 1.
Phytol effect on skin-related genes in 3D epidermal skin equivalent (EPI200).
| Gene | Fold regulation |
|---|---|
| FN1 | 3.61 |
| KLK6 | 2.27 |
| HBEGF | 2.23 |
| TNC | 2.01 |
| LOR | 1.83 |
| ALOX12B | 1.48 |
| HAS3 | 1.44 |
| ALOX12 | 1.44 |
| PTGS2 | −1.22 |
| MMP3 | −3.11 |
Results are shown as up-down regulation compared to control group. Phytol significantly (p < 0.05) increased gene expression of Fibronectin 1 (FN1), Kallikrein-6 (KLK6), Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HBEFG), Tenascin C (TNC), Loricrin (LOR), Arachidonate 12-lipoxygenase B (ALOX12B), Hyaluronan synthase 3 (HAS3), and Arachidonate 12-lipoxygenase (ALOX12). Phytol significantly (p < 0.05) decreased the gene expression of prostaglandin-endoperoxide synthase 2 (PTGS2) and matrix metalloproteinase-3 (MMP3).