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. 2021 Sep 17;8:724344. doi: 10.3389/fmed.2021.724344

Table 2.

The effect of active ingredient application on pro-collagen I in human dermal fibroblasts in vitro.

Ingredient A Ingredient B A B A+B combined A/B rotation B/A rotation
% change in pro-collagen I production
Phytol 0.0001% Retinol 0.00003% 19.1 3.9 7.09 75.7* 92.6*

Rotational treatment led to a significant (p < 0.05) increase in pro-collagen I production compared to other treatments.

*

Means p < 0.05 or statistically significant result.