Table 3.
Effects of PL-02 on biochemical parameters.
| Parameter | Vehicle | PL-02-1X | PL-02-2X | PL-02-5X | Trend analysis |
|---|---|---|---|---|---|
| AST (U/L) | 82 ± 7 | 81 ± 8 | 82 ± 7 | 82 ± 6 | 0.7425 |
| ALT (U/L) | 57 ± 18 | 55 ± 8 | 55 ± 8 | 56 ± 8 | 0.0367 |
| CK (U/L) | 563 ± 74 | 568 ± 73 | 564 ± 38 | 571 ± 61 | 0.7962 |
| GLU (mg/dL) | 228 ± 16 | 228 ± 38 | 226 ± 15 | 227 ± 51 | 0.7189 |
| CREA (mg/dL) | 0.39 ± 0.01 | 0.38 ± 0.01 | 0.38 ± 0.01 | 0.38 ± 0.03 | 0.0474* |
| BUN (mg/dL) | 22.4 ± 2.5 | 22.8 ± 2.5 | 22.3 ± 2.8 | 22.8 ± 1.9 | 0.6891 |
| UA (mg/dL) | 1.3 ± 0.3 | 1.3 ± 0.2 | 1.3 ± 0.3 | 1.3 ± 0.2 | 0.5371 |
| TC (mg/dL) | 152 ± 8 | 152 ± 13 | 152 ± 20 | 152 ± 12 | 0.9640 |
| TG (mg/dL) | 157 ± 21 | 163 ± 39 | 156 ± 12 | 156 ± 30 | 0.9822 |
| ALB (g/dL) | 3.3 ± 0.1 | 3.3 ± 0.1 | 3.3 ± 0.1 | 3.3 ± 0.2 | 0.6818 |
| TP (g/dL) | 5.7 ± 0.3 | 5.7 ± 0.2 | 5.7 ± 0.2 | 5.7 ± 0.3 | 0.9014 |
Data are expressed as mean ± SD (n = 10 mice per group).
AST, aspartate aminotransferase; ALT, alanine transaminase; CK, creatine kinase; GLU, glucose; CREA, creatinine; BUN, blood urea nitrogen; UA, uric acid; TC, total cholesterol; TG, triacylglycerol; ALB, albumin; TP, total protein.