Table 4:
Comparison of NPI Constructs between Cognitively Normal Controls, Alzheimer Disease, and Dementia with Lewy Bodies
| Variable | Symptoms Present (%) | Severity Scores (Mean±SD) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Controls (n=53) | AD (n=78) | DLB (n=110) | Overall p-value | Post-hoc AD vs DLB | Controls (n=53) | AD (n=78) | DLB (n=110) | Overall p-value | Post-hoc AD vs DLB | |
| Delusions | 2.3 | 16.7 | 28.2 | .002 | .17 | 0.0 (0.1) | 0.2 (0.5) | 0.5 (0.9) | .001 | .09 |
| Hallucinations | 0.0 | 4.8 | 35.2 | <.001 | <.001 | 0.0 (0.0) | 0.1 (0.5) | 0.6 (0.9) | <.001 | <.001 |
| Agitation | 18.2 | 42.9 | 56.3 | <.001 | .17 | 0.2 (0.4) | 0.6 (0.7) | 0.9 (0.9) | <.001 | .05 |
| Depression | 22.7 | 53.7 | 69.0 | <.001 | .10 | 0.3 (0.6) | 0.8 (0.9) | 1.1 (0.9) | <.001 | .21 |
| Anxiety | 9.1 | 45.2 | 42.3 | <.001 | .76 | 0.1 (0.4) | 0.6 (0.8) | 0.6 (0.9) | <.001 | .98 |
| Elation | 9.1 | 0.0 | 4.2 | .13 | .18 | 0.1 (0.3) | 0.0 (0.0) | 0.1 (0.3) | .238 | .48 |
| Apathy | 4.5 | 47.6 | 71.8 | <.001 | .01 | 0.0 (0.2) | 0.7 (0.9) | 1.3 (1.1) | <.001 | .001 |
| Disinhibition | 9.1 | 23.8 | 19.7 | .17 | .61 | 0.1 (0.2) | 0.3 (0.7) | 0.4 (0.8) | .063 | .97 |
| Irritability | 27.3 | 41.5 | 60.5 | .002 | .05 | 0.3 (0.4) | 0.5 (0.7) | 1.0 (1.0) | <.001 | .02 |
| Aberrant Motor | 0.0 | 23.8 | 33.8 | <.001 | .26 | 0.0 (0.0) | 0.4 (0.8) | 0.7 (1.1) | <.001 | .19 |
| Nighttime Behaviors | 20.5 | 38.1 | 64.8 | <.001 | .006 | 0.2 (0.5) | 0.6 (0.8) | 1.3 (1.2) | <.001 | <.001 |
| Appetite | 9.3 | 42.9 | 45.7 | <.001 | .77 | 0.1 (0.3) | 0.6 (0.8) | 0.8 (1.0) | <.001 | .50 |
Mean (SD) or %
KEY: AD=Alzheimer’s disease; DLB=Dementia with Lewy bodies; NPI=Neuropsychiatric Inventory
Bold indicates post-hoc significance for AD vs DLB after correction for multiple comparisons (corrected p-value<.005)