Table 6:
Comparison of LBD-MOD Sleep, Parasomnia, Fluctuation, and Alertness Constructs between Cognitively Normal Controls, Alzheimer Disease, and Dementia with Lewy Bodies
| Variable | Controls (n=53) | AD (n=78) | DLB (n=110) | Overall p-value | Post-hoc AD vs DLB |
|---|---|---|---|---|---|
| SCOPA-Sleep, Nighttime, Mean (SD) | 3.6 (3.1) | 3.8 (3.1) | 3.9 (4.0) | .90 | .99 |
| SCOPA-Sleep, Sleep Quality, Mean (SD) | 2.6 (1.4) | 2.8 (1.5) | 3.1 (1.8) | .236 | .41 |
| SCOPA-Sleep, Daytime Sleepiness, Mean (SD) | 2.1 (2.0) | 3.4 (3.4) | 6.4 (4.6) | <.001 | <.001 |
| Mayo Sleep: RBD, % | 17.3 | 20.5 | 64.5 | <.001 | <.001 |
| Mayo Sleep: PLMS, % | 2.0 | 15.4 | 29.1 | <.001 | .03 |
| Mayo Sleep: RLS, % | 9.6 | 9.1 | 22.7 | .02 | .01 |
| Mayo Sleep: Snort, % | 16.0 | 15.4 | 37.3 | .001 | .001 |
| Mayo Sleep: Apnea, % | 14.9 | 19.4 | 27.3 | .21 | .26 |
| Alertness, Mean (SD) | 9.3 (1.1) | 8.1 (1.6) | 6.4 (2.1) | <.001 | <.001 |
| Mayo Fluctuations Total, Mean (SD) | 0.3 (0.6) | 1.2 (0.9) | 2.7 (1.3) | <.001 | <.001 |
| Drowsy, % | 16.3 | 30.3 | 70.7 | <.001 | <.001 |
| Sleeps >2hrs, % | 2.0 | 11.8 | 55.2 | <.001 | <.001 |
| Flow of ideas, % | 2.0 | 36.4 | 75.9 | <.001 | <.001 |
| Stares, % | 4.1 | 20.0 | 51.7 | <.001 | .002 |
Mean (SD) or %
KEY: AD=Alzheimer’s disease; DLB=Dementia with Lewy bodies; SCOPA= Scales for Outcomes in Parkinson’s disease
RBD=Rapid eye movement sleep behavioral disorder; PLMS=Periodic leg movements of sleep; RLS=Restless legs syndrome
Bold indicates post-hoc significance for AD vs DLB after correction for multiple comparisons (corrected p-value<.004)