Table 7:
Comparison of UDS and LBD-MOD Neuropsychological Test Battery between Cognitively Normal Controls, Alzheimer Disease, and Dementia with Lewy Bodies
Test Variable | Controls (n=53) | AD (n=78) | DLB (n=110) | Overall p-value | Post-hoc AD vs DLB |
---|---|---|---|---|---|
MoCA | 26.6 (2.5) | 13.8 (6.0) | 14.2 (5.9) | <.001 | .75 |
Numbers Forward | 7.4 (1.4) | 6.0 91.50 | 6.4 (1.5) | <.001 | .21 |
Numbers Backward | 5.6 (1.50 | 3.6 (1.60 | 3.6 (1.4) | <.001 | .93 |
Trailmaking A, seconds | 29.5 (10.9) | 73.3 (42.1) | 98.3 (50.2) | <.001 | <.001 |
Trailmaking B, seconds | 70.2 (41.1) | 153.3 (41.1) | 164.9 (33.8) | <.001 | .22 |
Animal Naming | 20.7 (4.5) | 9.1 (4.8) | 9.7 (4.7) | <.001 | .64 |
MINT | 14.9 (0.4) | 11.2 (4.1) | 13.2 (2.9) | <.001 | <.001 |
HVLT – Immediate | 24.2 (3.9) | 9.6 (4.9) | 10.2 (4.9) | <.001 | .64 |
HVLT – Delay | 9.4 (1.7) | 0.9 (1.6) | 1.9 (2.1) | <.001 | <.001 |
HVLT – Recognition | 11.7 (0.4) | 5.8 (3.1) | 7.6 (2.1) | <.001 | <.001 |
Noise Pareidolia – Correct Faces | 6.9 (0.4) | 6.0 (1.4) | 5.9 (1.4) | <.001 | .79 |
Noise Pareidolia – Correct Noise | 12.7 (0.8) | 11.7 (1.8) | 9.0 (3.7) | <.001 | <.001 |
Noise Pareidolia – Total Correct | 19.6 (1.0) | 17.3 (3.1) | 15.4 (4.3) | <.001 | <.001 |
Noise Pareidolia – Total Pareidolia | 0.3 (0.7) | 2.2 (2.9) | 4.0 (3.9) | <.001 | <.001 |
Mean (SD)
KEY: UDS=Uniform Data Set; LBD-MOD=Dementia with Lewy Bodies Module; AD=Alzheimer’s disease; DLB=Dementia with Lewy bodies; MoCA=Montreal Cognitive Assessment; MINT=Multilingual Naming Test; HVLT=Hopkins Verbal Learning Test
Bold indicates post-hoc significance for AD vs DLB after correction for multiple comparisons (corrected p-value <.004)