Table 8:
Comparison of UDS and LBD-MOD Measures to Distinguish MCI due to AD from MCI due to DLB
| Variable | MCI-AD n=79 | MCI-DLB n=22 | p-value |
|---|---|---|---|
| Age, y | 73.5 (8.8) | 75.3 (5.3) | .37 |
| Sex, %M | 51.9 | 68.7 | .17 |
| Education, y | 15.9 (2.6) | 17.0 (2.0) | .09 |
| Hachinski | 0.7 (0.8) | 0.7 (0.9) | .74 |
| FAQ | 2.6 (3.6) | 3.4 (4.8) | .42 |
| NPI | 4.3 (3.9) | 6.3 (5.9) | .06 |
| Depression, % | 28.8 | 64.3 | .01 |
| Depression, Total | 0.4 (0.7) | 1.1 (0.9) | .004 |
| Anxiety, % | 18.6 | 46.7 | .02 |
| Anxiety, Total | 0.2 (0.5) | 0.7 (0.8) | .005 |
| Apathy, % | 27.1 | 46.7 | .14 |
| Apathy, Total | 0.4 (0.7) | 0.8 (1.0) | .09 |
| CDR | 0.5 (0.1) | 0.6 (0.3) | .10 |
| CDR-SB | 1.3 (0.9) | 1.9 (1.4) | .02 |
| Memory | 0.5 (0.10 | 0.5 (0.1) | 1.0 |
| Orientation | 0.1 (0.3) | 0.2 (0.3) | .39 |
| Judgment/Problem Solving | 0.4 (0.3) | 0.5 (0.3) | .04 |
| Community Affairs | 0.1 (0.2) | 0.3 (0.4) | .009 |
| Home & Hobbies | 0.1 (0.2) | 0.2 (0.3) | .27 |
| Personal Care | 0.0 (0.2) | 0.2 (0.4) | .04 |
| UPDRS | 3.0 (3.9) | 14.9 (11.6) | <.001 |
| Hoehn & Yahr | 0.1 (0.5) | 1.5 (1.2) | <.001 |
| Total Autonomic Features | 3.1 (2.5) | 5.6 (3.2) | <.001 |
| Dysphagia, % | 5.3 | 19.0 | .04 |
| Decrease libido, % | 22.4 | 42.9 | .06 |
| Decrease sexual performance, % | 25.0 | 52.4 | .02 |
| Double vision, % | 2.6 | 19.0 | .006 |
| Constipation, % | 21.1 | 61.9 | <.001 |
| Obstipation, % | 14.5 | 42.9 | .004 |
| Incomplete emptying of bladder, % | 19.7 | 38.1 | .08 |
| Lightheaded with change in position, % | 17.1 | 33.3 | .10 |
| Lightheaded with prolonged standing, % | 6.6 | 19.0 | .08 |
| Fainting, % | 2.6 | 14.3 | .03 |
| Mayo Fluctuations | 0.8 (0.9) | 1.7 (1.1) | <.001 |
| Mayo Sleep RBD, % | 22.1 | 38.1 | .14 |
| SCOPA-Sleep Daytime Sleepiness | 3.6 (3.0) | 3.3 (2.9) | .73 |
| Trailmaking A, seconds | 34.7 (11.6) | 45.1 (22.1) | .003 |
| Trailmaking B, seconds | 92.5 (40.1) | 126.9 (41.2) | .001 |
| Noise Pareidolia – Correct Faces | 6.8 (0.3) | 6.5 (1.1) | .01 |
| Noise Pareidolia – Correct Noise | 12.2 (1.6) | 11.0 (2.3) | .02 |
| Noise Pareidolia – Total Correct | 19.2 (1.6) | 17.7 (2.5) | .001 |
| Noise Pareidolia – Total Pareidolia | 0.7 (1.5) | 1.9 (2.2) | .005 |
Mean (SD) or %
KEY: UDS=Uniform Data Set; LBD-MOD=Dementia with Lewy Bodies Module; MCI-AD=mild cognitive impairment due to Alzheimer’s disease; MCI-DLB=mild cognitive impairment due to dementia with Lewy bodies; FAQ=Functional Activities Questionnaire; NPI=Neuropsychiatric Inventory; CDR=Clinical Dementia Rating; CDR-SB=CDR Sum of boxes; UPDRS=Unified Parkinson’s Disease Rating Scale; RBD=Rapid eye movement sleep behavioral disorder; SCOPA= Scales for Outcomes in Parkinson’s disease
Bold indicates significance after correction for multiple comparisons (corrected p-value<.006)