Table 9:
Alignment of Classification of the LBD-MOD with the Lewy Body Composite Risk Score
| LBCRS Variable | Controls (n=53) | AD (n=78) | DLB (n=110) | Overall p-value | Post-hoc AD vs DLB | MCI-AD (n=79) | MCI-DLB (n=22) | p-value |
|---|---|---|---|---|---|---|---|---|
| Bradykinesia, % | 11.1 | 33.3 | 98.6 | <.001 | <.001 | 17.2 | 73.3 | <.001 |
| Rigidity, % | 2.2 | 7.1 | 38.9 | <.001 | <.001 | 5.2 | 26.7 | .01 |
| Postural Instability, % | 11.1 | 26.2 | 69.4 | <.001 | <.001 | 19.0 | 46.7 | .03 |
| Rest Tremor, % | 2.2 | 2.4 | 27.8 | <.001 | <.001 | 3.4 | 26.7 | .004 |
| Daytime Sleepiness, % | 22.2 | 54.8 | 80.6 | <.001 | <.001 | 37.9 | 66.7 | .05 |
| Illogical Thoughts, % | 6.7 | 31.7 | 75.0 | <.001 | <.001 | 8.6 | 26.7 | .06 |
| Staring, % | 2.3 | 19.0 | 60.6 | <.001 | <.001 | 12.1 | 33.3 | .05 |
| Hallucinations, % | 0.0 | 0.0 | 47.9 | <.001 | <.001 | 0.0 | 6.7 | .05 |
| RBD, % | 15.6 | 21.4 | 61.1 | <.001 | <.001 | 12.1 | 26.7 | .16 |
| Orthostatic, % | 11.1 | 7.1 | 36.1 | <.001 | <.001 | 1.7 | 13.3 | .04 |
| Total, Mean (SD) | 0.8 (1.2) | 1.9 (1.2) | 60. (1.7) | <.001 | <.001 | 1.2 (1.1) | 3.8 (1.4) | <.001 |
Mean (SD) or %
KEY: LBD-MOD=Dementia with Lewy Bodies Module; LBCRS=Lewy body composite risk score; AD=Alzheimer’s disease; DLB=Dementia with Lewy bodies; MCI-AD=mild cognitive impairment due to Alzheimer’s disease; MCI-DLB=mild cognitive impairment due to dementia with Lewy bodies; RBD=Rapid eye movement sleep behavioral disorder
Bold indicates post-hoc significance after correction for multiple comparisons (corrected p-value<.005)