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. Author manuscript; available in PMC: 2022 Jun 5.
Published in final edited form as: Dev Dyn. 2021 Apr 8;251(6):988–1003. doi: 10.1002/dvdy.340

Figure 1. Sequence conservation of axolotl TLRs.

Figure 1.

(A) Representative phylogenetic tree of orthologous TLR2-4 generated by MEGA X. Scale bar indicates the evolutionary distance of 0.2 amino acid substitutions per site in the TLRs. (B) Abbreviations of annotations: LRR-NT = leucine-rich repeat N-terminal. LRR = leucine-rich repeat. LRR-CT = leucine-rich repeat C-terminal. LRR-TYP = leucine-rich repeat typical. TIR = toll/interleukin-1 receptor homology domain. Pink rectangle indicates low-complexity region. Blue rectangle represents the transmembrane domain. (C-F) Comparison of the SMART predicted domain structure of axolotl TLR2-4 to other vertebrate species.