Cutaneous melanoma remains a severe public health threat, with annual incidence increasing slowly but steadily over 4 decades. Immunotherapy has only been a feasible therapeutic option for cutaneous melanoma in the last 30 years

The pembrolizumab, nivolumab and ipilimumab have been approved by the FDA for melanoma treatment. The first FDA-approved immune checkpoint inhibitor in metastatic melanoma is ipilimumab, a human monoclonal IgG1 antibody against CTLA-4

High dosages of IL-2 and interferons are the most commonly utilized drugs in biological immunotherapy

The first class of immunomodulatory drugs to be used in the treatment of melanoma is cytokines. Indeed, the FDA has approved both IL-2 and IFN-α as adjuvant treatments for melanoma