Fig. 3.

eCDF curves of observed changes from baseline to week 16 in P-SIM item scores by PASI absolute score category. a P-SIM item 1 (itching). b P-SIM item 3 (skin pain). c P-SIM item 5 (scaling). Data were pooled from BE VIVID and BE READY. Negative changes from baseline in P-SIM item scores indicate improvement. Dotted lines show median values. eCDFs for itching, skin pain and scaling items are shown as these items were used as efficacy endpoints in the BE VIVID and BE READY trials; findings for other items were similar. eCDF empirical cumulative distribution function, PASI Psoriasis Area and Severity Index, P-SIM Psoriasis Symptoms and Impacts Measure