Table 2.

Characteristics of 184 individuals with BD-I (92 sex-matched proband-parent pairs)

	Cumulative probability		Median age at onset in years (interquartile range)
	Number	(%)^c	Median age at onset in years (interquartile range)
Females	100	54.3
Age at onset of BD			19 (15.3, 26.0)
Duration of BD			20.3 (10.3, 35.8)
Lifetime comorbidities:
≥ 1 comorbid mental disorder^a	95	51.6
Age at onset of first mental disorder^b			15.0 (10.5, 17.8)
Social phobia	9	5	14.5 (9.0, 20.3)
Specific phobia	14	7.5	9.0 (6.3, 13.8)
Obsessive compulsive disorder	6	3.3	17.5 (11.5, 28.0)
Generalized anxiety disorder	30	16.3	21.8 (17.0, 27.3)
Agoraphobia	12	6.5	17.8 (12.3, 28.0)
Panic disorder	33	18.0	23.0 (15.5, 32.3)
Eating disorder	11	6.0	17 (12.8, 22.5)
Substance use disorder	23	12.5	18.0 (15.8, 25.3)
Alcohol use disorder	58	31.5	28.3 (23.0, 37.5)

^aComorbid mental disorder refers to any DSM IV diagnosed disorder that occurred (irrespective of BD-I mood episodes);

^bFirst mental disorder refers to a clinical condition that met criteria for a full-threshold DSM IV diagnosis

^cDenominator for comorbid disorders ranges from n = 175 to n = 184 (due to small number of sporadic missing values)