Rosacea is a chronic inflammatory skin disease characterized by centrofacial erythema, papules, pustules, and telangiectasias.

Mast cells play an integral role in the pathogenesis of rosacea via the activation and secretion of various immune mediators.

Several existing and emerging topical, oral, and injectable therapeutics have been associated with improvement of rosacea symptoms based on their anti-mast cell properties.

This review may serve as a resource for clinicians and researchers exploring alternative rosacea treatments focused on mast cell stabilization.

Large-scale clinical studies are needed to determine the true efficacy of mast cell inhibitory agents in the treatment of rosacea.