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In vitro whole blood assays for JAK 1/2/3 and TYK2 inhibitors
| Signaling kinase | Stimulant | Endpoint |
|---|---|---|
| JAK 1/3 | IL-2 | STAT5 phosphorylation in T cells |
| JAK 2/2 | TPO | STAT3 phosphorylation in platelets |
| TYK2/JAK 2 | IL-12 | IFN-γ production in whole blood |
IFN interferon, IL interleukin, JAK Janus kinase, STAT signal transducer and activator of transcription, TPO thrombopoietin, TYK2 tyrosine kinase 2
